Regarding the area, Posavska is the second smallest region in Slovenia. Nevertheless, with 968 square kilometres it is twice as large as the smallest region, Zasavska. The Posavska statistical region had about 4% of Slovenia’s population in 2023. With a population density of 79 inhabitants per square kilometre, it ranked among the less densely populated regions in the country.

The mean age of the population was 44.8 years. The share of the region's population aged 0–14 was 14.8%, slightly below the national average of 14.9%, while the share of the population aged 65+ was 22.6%, 1 percentage point higher than the national average. The region recorded a natural decrease, while net migration was positive. Total increase was 42 persons or 0.6 per 1,000 population. The mean age of mother at birth of children was the lowest in this region. The number of live births in the Posavska region was 8.9 per 1,000 population, the second highest after Jugovzhodna Slovenija, which recorded 9.5 per 1,000 population. The total fertility rate—representing the average number of live births per woman of reproductive age (15–49 years) in a calendar year—was also the second highest in Posavska, standing at 1.8. Only Jugovzhodna Slovenija had a higher rate, at 1.9. On average, women in Posavska gave birth at the age of 30.7 years. The share of mothers under the age of 20 was the second highest in this region (1.8%). The share of the population (25–64 years) with tertiary education was at 28.2% the fourth lowest, while the share of the population with basic education or less was at 13.2%. The region had a high share of residents with at most secondary education (58.6%). Posavska also ranked among the regions with the highest number of graduates per 1,000 population; like five other regions, it recorded 8 graduates per 1,000 population.

In 2023, the employment rate in Posavska was slightly above the national average, standing at 70.7%. The gap between the employment rate for men (75.8%) and the employment rate for women (64.9%) was the second highest at 10.9 percentage points. The LFS unemployment rate was the third lowest, at 3.0%. More than a third of the persons in employment in the region worked outside the region of residence (36%). Average monthly net earnings were EUR 60 below the national average; they amounted to EUR 1,385.

The gross domestic product per capita amounted to EUR 24,729 and was 18% lower than the national average. The region's gross value added accounted for 2.9% of Slovenia's total GVA. Disposable income per capita in the region amounted to EUR 16,552 and was less than 1% below the national average. The region had about 6.500 enterprises, which on average employed 4 people.

Residents of this region assessed their overall life satisfaction with 7.8 out of 10, exceeding the Slovenian average of 7.7. The same level of satisfaction was expressed by residents of Jugovzhodna Slovenija and the Osrednjeslovenska region. The at-risk-of-poverty rate was 11.1%, while the risk of social exclusion rate was 12.3%. Both were among the lowest in Slovenia and below the national average. The region also stood out for having the second-highest number of convicted persons (adults and juveniles) among the regions with 2.8 per 1,000 population. However, this figure was still half that of Jugovzhodna Slovenija (5.4 per 1,000 population). The region ranks third in the number of passenger cars per 1,000 population (613) and their age (11.8 years).

In the region, 511 kg of municipal waste was generated per capita. This was 7 kilograms per capita less than the average for Slovenia. 73.8% of generated municipal waste in the region was separately collected.